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Anaemia, iron deficiency 

Introduction 

Anaemia occurs when there is a reduced number of red blood cells. This can be caused by an iron deficiency.

About the blood

Blood contains a fluid called plasma, which includes three different types of cells:

  • White blood cells are part of the body's immune system and defend it against infection.
  • Red blood cells carry oxygen around the body in a substance called haemoglobin.
  • Platelets help the blood to clot.

Haemoglobin

Haemoglobin acts as a sort of transport mechanism for the blood. As blood passes through the lungs, the haemoglobin pulls in oxygen molecules and releases carbon dioxide molecules.

After moving away from the lungs, the haemoglobin delivers the oxygen molecules to the body’s tissue and absorbs any excess carbon dioxide molecules to take back to the lungs.

Bone marrow

Red blood cells, which contain haemoglobin, are produced in the bone marrow (a red spongy material that is found inside the larger bones). Millions of new cells are produced every day to replace old cells that break down.

Nutrients from food, such as iron and certain vitamins, ensure that your bone marrow remains healthy and is able to produce a constant supply of red blood cells.

Iron deficiency anaemia occurs when there is a reduced number of red blood cells because the body does not have enough iron to produce them. The main symptoms are tiredness and lethargy (lack of energy).

Anaemia

There are several different types of anaemia and each one has a different cause. The most common type of anaemia is iron deficiency anaemia, which this article focuses on.

Other forms of anaemia can be caused by a lack of vitamin B12 or folate in the body.

See the Health A-Z topic about Vitamin B12 and folate deficiency anaemia for more information about this condition.

Iron

Iron is found in meat, dried fruit and some vegetables. It is used by the body to make haemoglobin, which helps store and carry oxygen in red blood cells (see box, left).

Haemoglobin transports oxygen from the lungs to the rest of the body. If there is a lack of iron in the blood, the organs and tissues will not get as much oxygen as they usually do.

How common is iron deficiency anaemia?

Iron deficiency anaemia affects up to 1 in 20 men and 1 in 20 post-menopausal women (after a woman’s monthly periods have stopped).

Iron deficiency anaemia may be more common in women who are still menstruating (having periods). This is because menstruation and pregnancy can cause iron deficiency.   

Outlook

Treatment for iron deficiency anaemia involves taking iron supplements to replace the missing iron in the body. This is usually very effective and the condition rarely causes any serious complications.

If you have iron deficiency anaemia, you will need to be monitored every few months to check that the treatment is working and that your iron levels have returned to normal.

In some cases, further tests may be necessary to determine the underlying cause of your iron deficiency anaemia. In men, the most common cause is bleeding in the gastrointestinal tract (the stomach and intestines), which may require separate treatment.

  • show glossary terms

Blood
Blood supplies oxygen to the body and removes carbon dioxide. It is pumped around the body by the heart.

Bone marrow
Bone marrow is the soft, spongy tissue in the centre of bones that produces blood cells.

Deficiency
If you have a deficiency, you are lacking in a particular substance needed by the body.

Intestines
The intestines are part of the digestive system, between the stomach and the anus, which digest and absorb food and liquid.

Plasma
Plasma is the liquid part of blood, which holds other blood cells together.

Stomach
The sac-like organ of the digestive system. It helps digest food by churning it and mixing it with acids to break it down into smaller pieces.

Last reviewed: 23/04/2010

Next review due: 23/04/2012

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Comments are personal views. Any information they give has not been checked and may not be accurate.

jomc20 said on 04 September 2011

I think from other comments on this page that people are expecting advice from the NHS. THis is just a forum for patients to comment. I am not a health professional but I can't help wondering if our poor diet is to blame for the many cases of anaemia these days. In other countries parents give their children the best quality food they can afford. Here in Britain they seem to live on fast food and frozen processed food such as chips, pizza, chicken nuggets etc. This cannot be good for growing bones or for the immune system. I am sure this is why an in-law's daughter is thin and sickly and not growing as she should for her age (12). Adults, too, skip meals, are obese and don't cook fresh food. My mother (80) just had major surgery and was anaemic as a result but she is already getting over the anaemia due to iron sulphate tablets (cause bad constipation!) and a healthy diet of fish, red meat and home-grown vegetables.

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cmilnedunn said on 23 April 2011

It may be worth considering an Iron Infusion instead of blood transfusions - or have kidney test (bloods) done to see if these are working property or if you are low in b12? which helps absorption. also heavy periods can cause anemia. what ever problem that you have anaemia can and does make you feel very ill as the levels get lower. excessively tired, palpertations very pale, ulcers etc.
It is worth being persistant with the doctors and although they may prescribe iron tablets/tonic this must be taken and if it does not work, insist that you go and see a specialist and have everything checked out.
It has taken me many years of feeling very sick to finally find the answer. I have been in and out of hospital a&e with them not finding the problems. I have stage 3 Kidney Disease and excessively bad periods (im 46) but once this was diagnosed I had an iron infusion and all the other symptoms dissapeared - and I got my life back for 7/8 months, now Im waiting for another one. its like a miracle and worth the long haul of diagnosis !

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justinagc said on 16 December 2010

my son 5 years old has been sick for all the year past.from nov.2009 until now dec 2010.all the time had an infection ,or tonssilitis inflamated,or get a virus .every mounth during from last year,he get prescription with antibiotics and a lot of paracetamol and nurofen.I ask my doctor why he's geting sick all the time ,and he was telling me i's normal,many children get sick on this age .I ask my doctor for a blood test to many times,and he telling me i's not nesesary.now my son is again sick with prescription of antibiotics,and I deceided to go for a private clinic, to do the blood test. I 've got the result of the blood test and my son had a very low iron and calcium,and now I got the answer ,WHY MY SON GETTING SICK ALL THE TIME.!!!!WHY MY DOCTOR DOESN'T REFER US FOR A BLOOD TEST?WHAT CAN I DO NEXT?THANK YOU! regards ANDREW'S MUM

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TPK said on 19 June 2010

This is for Maurizio:

My partner has similar symptoms and she has been diagnosed 3 days ago with hypothyroidism. I suggest you ask your partner's GP to get her blood tests done for thyroid levels. Hope you nail down the cause.

Regards,
Pav

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maestro40 said on 15 February 2010

My partner has a severe iron deficiency but we struggle to get serious treatment going through the NHS system.
Her symptoms have becoming increasingly alarming
rapid heartbeat, dizziness, headaches, pale skin, hair loss, being very tired all the time and sometimes mentally confused.
Still, every time she sees a GP they find very easy to blame it on heavy periods and refer her to an Haematologyst. The Haematologist cannot find anything and refer her to a Gynaecologist who also cannot find anything and refer her back to an Haematologist. Months go by and she struggle with her day to day life and our children are suffering because of this. Finally last year she was given a 5 session blood transfusion and after that she felt well for 6 months but since December all the symptoms are back again and actually worst then before. Again she had to go through many appointments with GP and specialists to get referred for a blood transfusion (one session only this time) which will probably fix the problem only for a month or two.
My questions are: Can the referral process for getting blood transfusion become faster now that the NHS has a record of her case and can more detailed exams be carried out to find out the source of her problem?
She could have internal bleeding caused by ulcers or at the worst cancer and if that is not going to kill her a heart attack will because she is continually out of breath which for a lean and active woman age 38 is not normal.
We would appreciate your advice as life has been hell for the last 3 years and we don't seem to be taken seriously by the GP's in our surgery.

Faithfully
Maurizio

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